(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

Base Information

Chemical Name:(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam
CAS No.:476359-34-9
Molecular Formula:C₃₄H₃₇FN₂O₅S
Molecular Weight:604.743
Hs Code.:

Synonyms:(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

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Chemical Property of (2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

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Technology Process of (2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

There total 1 articles about (2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 91407-48-6
2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene

: 138566-17-3
2-(benzhydrylideneamino)-1-(10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1.5]dec-4-yl)ethanone

: 476359-34-9
(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 50 ℃; for 10h;
DOI:10.1016/S0957-4166(02)00321-X

Reference yield: 86.0%

: 476359-34-9
(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

: 476359-38-3
(2R)-N-[(2S)-2-amino-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

Guidance literature:: With hydrogenchloride; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0957-4166(02)00321-X

Reference yield:

: 476359-34-9
(2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam

: 75290-51-6
3,4-dihydroxy-6-fluoro-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / aq. HCl / CH₂Cl₂ / 5 h / 20 °C

2: 82 percent / aq. LiOH / tetrahydrofuran / 1 h / 0 °C

3: 66 percent / aq. HBr / 1 h / 145 °C

With hydrogenchloride; lithium hydroxide; hydrogen bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(02)00321-X