75290-51-6

Usage

InChI:InChI=1/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1

Upstream product

• 853759-49-6 N-(tert-butoxycarbonyl)-3,4-di(tert-butoxycarbonyloxy)-6-fluoro-L-phenylalanine methyl ester 
• 59-92-7 levodopa 
• 300-48-1 3-O-methyldopa 
• 476359-34-9 (2R)-N-[(2S)-2-((diphenylmethylidene)amino)-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam 
• 476359-38-3 (2R)-N-[(2S)-2-amino-2-(2'-fluoro-4',5'-dimethoxybenzyl)-ethan-1-oyl]bornane-10,2-sultam 
• 75290-49-2 L-3-methoxy-4-hydroxyphenylalanine ethyl ester 
• 117831-96-6 (S)-3-(2-Fluoro-4,5-dimethoxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester 
• 117831-95-5 (S)-3-(3,4-Dimethoxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid ethyl ester 
• 91407-48-6 2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene 
• 476359-42-9 6-fluoro-L-3,4-dimethoxyphenylalanine 

Downstream Products

• 71144-39-3 6-Fluorodopamine 

Relevant academic research and scientific papers

Opportunities for isotopic labelling via phase-tagged synthesis with organogermanium linkers

Strategies for the use of germanium-based linkers for the phase-tagged synthesis of isotopically labelled intermediates are described. Protocols of potential use in the devolatilization of volatile intermediates prepared from [14C]-CO2/su

Method for making fluorine labled L-Dopa

The invention relates to a method for preparing F-Dopa and 18F-Dopa and intermediates that are useful in the method. The invention is a method that synthesizes F-Dopa and 18F-Dopa in good yield with high enantiopurity without the nee

Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA

Alkylation under phase transfer conditions of the chiral glycine synthon 2 (prepared from the commercially available Oppolzer chiral sultam) with fluorinated analogues of 3,4-dimethoxybenzyl chloride proceeded with high diastereoselectivity. Hydrolysis of

No-carrier-added (NCA) synthesis of 6-[18F]fluoro-L-DOPA using 3,5,6,7,8,8a-hexahydro-7,7,8a-trimethyl-[6S-(6α, 8α, 8αβ)]-6,8-methano-2H-1,4-benzoxazin-2-one

3,5,6,7,8,8a-Hexahydro-7,7,8a-trimethyl-[6S-(6α.8α.8αβ)]6,8-methano-2H-1,4 -benzoxazino-2-one (2) was investigated as chiral auxiliary for asymmetric NCA nucleophilic synthesis of 6-[18]Fluoro-L-DOPA. Direct condensation of 3,4-dimethoxy-2-[su

FLUORINATION OF SUBSTITUTED VERATROLES VIA REGIOSELECTIVE MERCURATION

A regioselective aromatic ring fluorination of substituted veratroles was achieved via a mercuration-fluorodemercuration reaction.

Aromatic fluorination with xenon difluoride: L-3,4-dihydroxy-6-fluoro-phenylalanine

L-3-Methoxy-4-hydroxyphenylalanine was fluorinated directly with XeF2 in CH2Cl2 at -60 deg C in vacuo.After hydrolysis with 48percent aqueous HBr, L-6-fluorodopa was obtained.The yield, based on XeF2, was 25percent.This reaction might be applied when chiral biomolecules are to be tagged with fluorine-18.