1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene

Base Information

Chemical Name:1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene
CAS No.:91407-48-6
Molecular Formula:C9H10 Cl F O2
Molecular Weight:204.63
Hs Code.:
DSSTox Substance ID:DTXSID50401220
Nikkaji Number:J1.784.919K
Wikidata:Q82204283
Mol file:91407-48-6.mol

Synonyms:91407-48-6;1-(chloromethyl)-2-fluoro-4,5-dimethoxybenzene;4,5-DIMETHOXY-2-FLUOROBENZYL CHLORIDE;SCHEMBL2542586;DTXSID50401220;FKDJCJSSPNZLOR-UHFFFAOYSA-N;AKOS009311490;(2-Fluoro-4,5-dimethoxybenzyl)chloride;2-fluoro-4,5-dimethoxy-benzyl chloride;FT-0690722;1-chloromethyl-2-fluoro-4,5-dimethoxybenzene;2-[(2-cyanoethyl)[4-[(6-nitrobenzothiazol-2-yl)azo]phenyl]amino]ethylacetate

Suppliers and Price of 1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4,5-DIMETHOXY-2-FLUOROBENZYL CHLORIDE 95.00%
5MG
$ 503.47

Alichem
4,5-Dimethoxy-2-fluorobenzylchloride
1g
$ 1445.30

Alichem
4,5-Dimethoxy-2-fluorobenzylchloride
500mg
$ 790.55

Alichem
4,5-Dimethoxy-2-fluorobenzylchloride
250mg
$ 494.40

Total 7 raw suppliers

Chemical Property of 1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene

Chemical Property:

Melting Point:50-54 °C(lit.)
Flash Point:>230 °F
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:204.0353354
Heavy Atom Count:13
Complexity:157

Purity/Quality:

99%+ ^*data from raw suppliers

4,5-DIMETHOXY-2-FLUOROBENZYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)CCl)F)OC
Uses (2-Fluoro-4,5-dimethoxybenzyl)chloride is an intermediate in the synthesis of 6-Fluoro L-DOPA Hydrobromide Salt (F591546), a fluorinated DOPA analog.

Technology Process of 1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene

There total 5 articles about 1-(Chloromethyl)-2-fluoro-4,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 71924-62-4
2-fluoro-4,5-dimethoxybenzaldehyde

: 91407-48-6
2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene

Guidance literature:: With hydrogenchloride; formaldehyd; In acetic acid; at 30 ℃;
DOI:10.1021/jo00371a032

Reference yield: 66.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 398-62-9
4-fluoroveratrole

: 91407-48-6
2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene

Guidance literature:: With hydrogenchloride; In acetic acid; for 1h;
DOI:10.1021/jm00166a009

Reference yield:

: 398-62-9
4-fluoroveratrole

: 91407-48-6
2-(chloromethyl)-4,5-dimethoxy-1-fluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / TiCl₄ / CH₂Cl₂ / 4.5 h

2: 98 percent / HCl gas, 37percent formalin / acetic acid / 30 °C

With hydrogenchloride; formaldehyd; titanium tetrachloride; In dichloromethane; acetic acid;
DOI:10.1021/jo00371a032