(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Base Information

Chemical Name:(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate
CAS No.:1369959-21-6
Molecular Formula:C₂₁H₂₃Cl₂N₃O₄
Molecular Weight:452.337
Hs Code.:

Synonyms:(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

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Chemical Property of (R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

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Technology Process of (R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

There total 6 articles about (R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1369959-20-5
4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

: 1369959-21-6
(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Guidance literature:: With Chiral cell AD column; In ethanol; n-heptane; optical yield given as %ee; Inert atmosphere; Resolution of racemate;
DOI:10.1021/jm201386u

Reference yield:

: 1369959-20-5
4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

: 1369959-21-6
(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

: 1369959-22-7
C₂₁H₂₃Cl₂N₃O₄

Guidance literature:: With Chiralcel OD column 50x500 mm; In n-heptane; isopropyl alcohol; Resolution of racemate;
DOI:10.1016/j.bmcl.2013.01.064

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1369959-21-6
(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / tetrahydrofuran; n-heptane / Heating; Inert atmosphere

2: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: Chiral cell AD column / ethanol; n-heptane / Inert atmosphere; Resolution of racemate

With piperidine; dmap; In tetrahydrofuran; ethanol; n-heptane; 1: Biginelli reaction;
DOI:10.1021/jm201386u