4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Base Information

• Chemical Name: 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate
• CAS No.: 1369959-20-5
• Molecular Formula: C₂₁H₂₃Cl₂N₃O₄
• Molecular Weight: 452.337
• Mol file: 1369959-20-5.mol

Synonyms:4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Chemical Property of 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate

There total 3 articles about 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate (1369959-19-2) → 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate (1369959-20-5)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm201386u

Reference yield:

acetoacetic acid methyl ester (105-45-3) → 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate (1369959-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / tetrahydrofuran; n-heptane / Heating; Inert atmosphere

2: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With piperidine; dmap; In tetrahydrofuran; n-heptane; 1: Biginelli reaction;

DOI:10.1021/jm201386u

Reference yield:

3,4-dichlorobenzaldehyde (6287-38-3) → 4-tert-butyl-6-methyl-7-(3,4-dichlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate (1369959-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / tetrahydrofuran; n-heptane / Heating; Inert atmosphere

2: dmap / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With piperidine; dmap; In tetrahydrofuran; n-heptane; 1: Biginelli reaction;

DOI:10.1021/jm201386u

upstream raw materials:

di-tert-butyl dicarbonate

methyl 7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

acetoacetic acid methyl ester

3,4-dichlorobenzaldehyde

Downstream raw materials:

(R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid

((R)-7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo-[1,5-a]pyrimidin-6-yl) ((S)-2-(4-fluorophenyl)pyrrolidin-1-yl)methanone

((R)-7-(3,4-dichlorophenyl)-2,5-dimethyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone

(R)-4-tert-butyl-6-methyl-7-(3 ,4-dichlorophenyl)-2, 5-dimethylpyrazolo[1,5-a]pyrimidine-4,6(7H)-dicarboxylate