Technology Process of (1S,5R)-1-(tosyloxymethyl)-7-methyl-2,6,8-trioxaspiro[4.5]decane
There total 8 articles about (1S,5R)-1-(tosyloxymethyl)-7-methyl-2,6,8-trioxaspiro[4.5]decane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.666667h;
DOI:10.1021/jo0341620
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 87 percent / hydrogen / Pd/C / methanol / 20 °C
2: 90 percent / sodium acetate; pyridinium chlorochromate; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 20 °C
3: 94 percent / tetrahydrofuran / 2 h / -78 °C
4: tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C
5: 3.15 g / aqueous NaOH; H2O2 / tetrahydrofuran; diethyl ether; H2O / 2 h / 0 °C
6: 79 percent / p-TsOH / CH2Cl2 / 24 h / 20 °C
7: 92 percent / n-Bu4NF / tetrahydrofuran / 12 h / 20 °C
8: 96 percent / triethylamine; DMAP / CH2Cl2 / 0.67 h / 0 °C
With
dmap; sodium hydroxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; sodium acetate; toluene-4-sulfonic acid; triethylamine; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo0341620
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / tetrahydrofuran / 2 h / -78 °C
2: tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C
3: 3.15 g / aqueous NaOH; H2O2 / tetrahydrofuran; diethyl ether; H2O / 2 h / 0 °C
4: 79 percent / p-TsOH / CH2Cl2 / 24 h / 20 °C
5: 92 percent / n-Bu4NF / tetrahydrofuran / 12 h / 20 °C
6: 96 percent / triethylamine; DMAP / CH2Cl2 / 0.67 h / 0 °C
With
dmap; sodium hydroxide; tetrabutyl ammonium fluoride; dihydrogen peroxide; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jo0341620
