(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

Base Information

Chemical Name:(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate
CAS No.:108666-30-4
Molecular Formula:C₈H₁₆O₄
Molecular Weight:176.213
Hs Code.:

(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-<isopropyl>propionate

Synonyms:(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

Chemical Property:

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Technology Process of (2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

There total 1 articles about (2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 64-17-5
ethanol

: 108739-57-7
(3R,5S,6S,9R)-3-((S)-1-Hydroxy-2-methyl-propyl)-9-methyl-6-(1-methyl-1-phenyl-ethyl)-1,4-dioxa-spiro[4.5]decan-2-one

: 205057-17-6
(5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexanone

: 108666-30-4
(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

Guidance literature:: With hydrogenchloride; for 2h; Heating;
DOI:10.1021/jo00390a044

Reference yield:

: 108666-30-4
(2R,3S)-(-)-ethyl 2,3-dihydroxy-3-propionate

: 10148-70-6
(2S,3S)-3-hydroxyleucine

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / CCl₄ / 2 h / Heating

2: RuCl₃*xH₂O, NaIO₄ / acetonitrile; H₂O / 2 h / Ambient temperature

3: NaN₃ / acetone; H₂O / 1.5 h / Ambient temperature

4: 20 percent aq. H₂SO₄ / diethyl ether / 24 h / Ambient temperature

5: 93 percent / 1 M aq. NaOH / tetrahydrofuran / 1.25 h / 0 °C

6: H₂ / 20 percent Pd(OH)2 on carbon / methanol / 48 h / 760 Torr / Ambient temperature

With ruthenium trichloride; sodium hydroxide; sodium periodate; thionyl chloride; sodium azide; sulfuric acid; hydrogen; palladium hydroxide - carbon; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; water; acetone; acetonitrile;
DOI:10.1016/S0040-4020(01)85384-9