Technology Process of 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-ol
There total 5 articles about 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 18 h / 150 °C
2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.33 h / -78 °C
2.2: 2 h / -78 - 20 °C
2.3: 4 h
3.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice
4.1: triethylamine; pyridine-SO3 complex / dimethyl sulfoxide / 0.33 h / 20 °C
5.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
6.2: 1 h / -78 - 20 °C
With
lithium borohydride; n-butyllithium; pyridine-SO3 complex; potassium hexamethylsilazane; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.33 h / -78 °C
1.2: 2 h / -78 - 20 °C
1.3: 4 h
2.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice
3.1: triethylamine; pyridine-SO3 complex / dimethyl sulfoxide / 0.33 h / 20 °C
4.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
5.2: 1 h / -78 - 20 °C
With
lithium borohydride; n-butyllithium; pyridine-SO3 complex; potassium hexamethylsilazane; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice
2.1: triethylamine; pyridine-SO3 complex / dimethyl sulfoxide / 0.33 h / 20 °C
3.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice
4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
4.2: 1 h / -78 - 20 °C
With
lithium borohydride; n-butyllithium; pyridine-SO3 complex; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; hexane; dimethyl sulfoxide;
