3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

Base Information

Chemical Name:3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole
CAS No.:1224950-10-0
Molecular Formula:C₃₃H₃₆N₂O₄
Molecular Weight:524.66
Hs Code.:

Synonyms:3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

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Chemical Property of 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

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Technology Process of 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

There total 9 articles about 3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1224950-09-7
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-one

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 1224950-10-0
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

Guidance literature:: 4-methoxyphenylhydrazine hydrochloride; With triethylamine; In ethanol; at 20 ℃; for 0.5h;

3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-one; In ethanol; at 20 ℃; for 15h;

Reference yield: 65.0%

: 4-methoxyphenylhydrazine hydrochloric acid salt

: 1224950-09-7
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-one

: 1224950-10-0
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

Guidance literature:: 4-methoxyphenylhydrazine hydrochloric acid salt; With triethylamine; In ethanol; at 20 ℃; for 0.5h;

3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(p-tolyl)propyn-1-one; In ethanol; at 20 ℃; for 14h;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1224950-10-0
3-(8-(benzyloxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl)-1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.33 h / -78 °C

1.2: 2 h / -78 - 20 °C

1.3: 4 h

2.1: lithium borohydride / tetrahydrofuran / 4 h / 70 °C / Cooling with ice

3.1: triethylamine; pyridine-SO₃ complex / dimethyl sulfoxide / 0.33 h / 20 °C

4.1: potassium carbonate / methanol / 1 h / 20 °C / Cooling with ice

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 13 h / 20 °C

7.1: triethylamine / ethanol / 0.5 h / 20 °C

7.2: 15 h / 20 °C

With manganese(IV) oxide; lithium borohydride; n-butyllithium; pyridine-SO₃ complex; potassium hexamethylsilazane; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene;