2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

Base Information

Chemical Name:2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide
CAS No.:1394938-95-4
Molecular Formula:C₁₉H₂₂F₃NO₄SSi
Molecular Weight:445.535
Hs Code.:

Synonyms:2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

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Chemical Property of 2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

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Technology Process of 2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

There total 6 articles about 2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394938-95-4
2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; dichloromethane; ethylene glycol; 3: Heck Reaction;

Reference yield:

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 1394938-63-6
N-(3-acetyl-2-fluorophenyl)-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

: 1394938-95-4
2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

Reference yield:

: 26120-86-5
2,5-difluorobenzenesulfonyl chloride

: 1394938-95-4
2,5-difluoro-N-(2-fluoro-3-{1-[(trimethylsilyl)oxy]ethenyl}phenyl)-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

5: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; dichloromethane; ethylene glycol; 3: Heck Reaction;