2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

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Chemical Name:2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide
CAS No.:1394939-12-8
Molecular Formula:C₂₇H₂₄F₃N₃O₄S₂
Molecular Weight:575.632
Hs Code.:

Synonyms:2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

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Chemical Property of 2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

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Technology Process of 2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

There total 14 articles about 2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1394939-75-3
N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide

: 181219-01-2
4-pyridineboronic acid pinacol ester

: 1394939-12-8
2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: N-{3-[5-bromo-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide; 4-pyridineboronic acid pinacol ester; With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 1.5h; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1394939-12-8
2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / ethylene glycol / 6 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

5.1: pyridinium perbromide hydrobromide / tetrahydrofuran / 1 h / Reflux

6.1: ethanol / 1 h / 60 °C

7.1: sodium acetate; acetic acid

7.2: 20 °C

8.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 100 °C / Inert atmosphere

With pyridine; hydrogenchloride; pyridinium perbromide hydrobromide; water; sodium acetate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethylene glycol; 3.1: Heck Reaction / 8.1: Suzuki Coupling;

Reference yield:

: 1394939-73-1
2,5-difluoro-N-{2-fluoro-3-[2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

: 1394939-12-8
2,5-difluoro-N-{2-fluoro-3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-N-(methoxymethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; acetic acid

1.2: 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 100 °C / Inert atmosphere

With sodium acetate; caesium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; 2.1: Suzuki Coupling;