[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

Base Information

Chemical Name:[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester
CAS No.:231303-21-2
Molecular Formula:C₂₀H₂₀Cl₃NO₄S
Molecular Weight:476.808
Hs Code.:

Synonyms:[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

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Chemical Property of [3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

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Technology Process of [3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

There total 1 articles about [3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 16630-66-3
methyl 2-(methylthio)acetate

: 5096-12-8
3-acetyl-N-benzylpyridinium chloride

: 4124-31-6
trichloroacetic acid anhydride

: 231303-21-2
[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

Guidance literature:: methyl 2-(methylthio)acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h;

3-acetyl-N-benzylpyridinium chloride; In tetrahydrofuran; at -70 - -40 ℃; for 1.5h;

trichloroacetic acid anhydride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1016/S0040-4039(99)00621-8

Reference yield: 70.0%

: 67-56-1
methanol

: 231303-21-2
[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

: 231303-26-7
5-acetyl-1-benzyl-4-methoxycarbonylmethyl-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: methanol; [3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester; With sodium methylate;

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; Heating;
DOI:10.1016/S0040-4039(99)00621-8

Reference yield:

: 231303-21-2
[3-Acetyl-1-benzyl-5-(2,2,2-trichloro-acetyl)-1,4-dihydro-pyridin-4-yl]-methylsulfanyl-acetic acid methyl ester

: (4R,5S)-5-Acetyl-1-benzyl-4-methoxycarbonylmethyl-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methoxide

1.2: 70 percent / Bu₃SnH; AIBN / benzene / Heating

2.1: 70 percent / H₂ / PtO₂ / ethyl acetate

With hydrogen; sodium methylate; platinum(IV) oxide; In ethyl acetate; 1.1: Substitution / 1.2: desulfurization / 2.1: Catalytic hydrogenation;
DOI:10.1016/S0040-4039(99)00621-8