ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide

Base Information

• Chemical Name: ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide
• CAS No.: 1356266-08-4
• Molecular Formula: C₁₉H₁₇NO₄S
• Molecular Weight: 355.414
• Mol file: 1356266-08-4.mol

Synonyms:ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide

Chemical Property of ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide

There total 2 articles about ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-phenylbenzo[d]isothiazole-1,1-dioxide (53440-57-6) + ethyl 2,3-butadienoate (14369-81-4) → ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide (1356266-08-4)

Guidance literature:

With triphenylphosphine; In toluene; at 20 ℃; for 72h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc16055b

Reference yield: 52.0%

3-phenylbenzo[d]isothiazole-1,1-dioxide (53440-57-6) + ethyl 2,3-butadienoate (14369-81-4) → ethyl 9b-phenyl-1,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-3-carboxylate 5,5-dioxide (1356266-07-3) + ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide (1356266-08-4) + (E)-ethyl 2-(4,4-dioxido-8b-phenyl-1H-azeto[1,2-b]benzo[d]isothiazol-2-(8bH)-ylidene)acetate (1356266-06-2)

Guidance literature:

With tributylphosphine; In toluene; at 20 ℃; for 72h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc16055b

Reference yield: 95.0%

ethyl 9b-phenyl-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide (1356266-08-4) → (±)-ethyl 9b-phenyl-1,2,3,9b-tetrahydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide

Guidance literature:

With palladium hydroxide, 20 wt% on carbon; hydrogen; In methanol; ethyl acetate; at 0 - 21 ℃; for 0.666667h; Schlenk technique;

DOI:10.1002/chem.201904175

upstream raw materials:

3-phenylbenzo[d]isothiazole-1,1-dioxide

ethyl 2,3-butadienoate