2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

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Chemical Name:2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid
CAS No.:1076220-92-2
Molecular Formula:C₂₅H₂₆BrF₃N₂O₄
Molecular Weight:555.392
Hs Code.:

Synonyms:2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

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Chemical Property of 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

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Technology Process of 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

There total 8 articles about 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076220-91-1
ethyl 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoate

: 1076220-92-2
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

Guidance literature:: With water; potassium hydroxide; In methanol; at 85 ℃; for 16h;

Reference yield:

: 103962-05-6
1-iodo-4-(trifluoromethoxy)benzene

: 1076220-92-2
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

5.2: 12 h / 0 - 20 °C

6.1: water; potassium hydroxide / methanol / 16 h / 85 °C

With copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; sodium hydride; triethylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;

Reference yield:

: 357193-01-2
ethyl 2-(4-amino-3-iodophenyl)-2-methylpropanoate

: 1076220-92-2
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium tribromide / tetrahydrofuran / 0.75 h / 20 °C

2.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4.2: 12 h / 0 - 20 °C

5.1: water; potassium hydroxide / methanol / 16 h / 85 °C

With copper(l) iodide; pyridinium tribromide; potassium tert-butylate; water; sodium hydride; triethylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;