2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

Base Information

Chemical Name:2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide
CAS No.:1076219-30-1
Molecular Formula:C₂₉H₃₅BrF₃N₃O₃
Molecular Weight:610.514
Hs Code.:

Synonyms:2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

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Chemical Property of 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

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Technology Process of 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

There total 9 articles about 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076220-92-2
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid

: 75-64-9
tert-butylamine

: 1076219-30-1
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

Guidance literature:: 2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-2-methylpropanoic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 - 20 ℃; for 0.75h;

tert-butylamine; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield:

: 103962-05-6
1-iodo-4-(trifluoromethoxy)benzene

: 1076219-30-1
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

5.2: 12 h / 0 - 20 °C

6.1: water; potassium hydroxide / methanol / 16 h / 85 °C

7.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.75 h / 0 - 20 °C

7.2: 6 h / 0 - 20 °C

With copper(l) iodide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; tetrabutyl ammonium fluoride; water; sodium hydride; triethylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 357193-01-2
ethyl 2-(4-amino-3-iodophenyl)-2-methylpropanoate

: 1076219-30-1
2-{7-bromo-1-[2-(tert-butylamino)-2-oxoethyl]-2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}-N-(tert-butyl)-2-methylpropionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium tribromide / tetrahydrofuran / 0.75 h / 20 °C

2.1: copper(l) iodide; triethylamine / trans-bis(triphenylphosphine)palladium dichloride / tetrahydrofuran / 3 h / 20 °C

3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4.2: 12 h / 0 - 20 °C

5.1: water; potassium hydroxide / methanol / 16 h / 85 °C

6.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.75 h / 0 - 20 °C

6.2: 6 h / 0 - 20 °C

With copper(l) iodide; pyridinium tribromide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium tert-butylate; water; sodium hydride; triethylamine; potassium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;