3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Base Information

Chemical Name:3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile
CAS No.:1260539-51-2
Molecular Formula:C₂₂H₁₅F₃N₈
Molecular Weight:448.41
Hs Code.:

Synonyms:3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Chemical Property of 3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

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Technology Process of 3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

There total 6 articles about 3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260538-76-8
4-(1H-imidazol-4-yl)-1-methyl-1H-pyrazole hydrochloride

: 1260539-50-1
4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

: 1260539-51-2
3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: With caesium carbonate; copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; In ethylene glycol; dimethyl sulfoxide; at 120 ℃; for 2h;

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1260539-51-2
3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate / 4 h / 100 °C

2: methanesulfonic acid / ethanol / 12 h / Reflux

3: isopropyl alcohol / 1 h / 100 °C

4: dothem / 1 h / 200 °C

5: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3 h / Reflux

6: caesium carbonate / copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline / ethylene glycol; dimethyl sulfoxide / 2 h / 120 °C

With thionyl chloride; methanesulfonic acid; caesium carbonate; hydrazine hydrate; copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; N,N-dimethyl-formamide; In ethanol; chloroform; dothem; ethylene glycol; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1187369-46-5
4-hydrazinyl-3-methylbenzonitrile

: 1260539-51-2
3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: methanesulfonic acid / ethanol / 12 h / Reflux

2: isopropyl alcohol / 1 h / 100 °C

3: dothem / 1 h / 200 °C

4: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3 h / Reflux

5: caesium carbonate / copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline / ethylene glycol; dimethyl sulfoxide / 2 h / 120 °C

With thionyl chloride; methanesulfonic acid; caesium carbonate; copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; N,N-dimethyl-formamide; In ethanol; chloroform; dothem; ethylene glycol; dimethyl sulfoxide; isopropyl alcohol;