4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

Base Information

Chemical Name:4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile
CAS No.:1260539-50-1
Molecular Formula:C₁₅H₈ClF₃N₄
Molecular Weight:336.704
Hs Code.:

Synonyms:4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

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Technology Process of 4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

There total 5 articles about 4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1260539-49-8
3-Methyl-4-{4-oxo-3-(trifluoromethyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

: 1260539-50-1
4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 3h; Reflux;

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1260539-50-1
4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / 4 h / 100 °C

2: methanesulfonic acid / ethanol / 12 h / Reflux

3: isopropyl alcohol / 1 h / 100 °C

4: dothem / 1 h / 200 °C

5: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3 h / Reflux

With thionyl chloride; methanesulfonic acid; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol; chloroform; dothem; isopropyl alcohol;

Reference yield:

: 1187369-46-5
4-hydrazinyl-3-methylbenzonitrile

: 1260539-50-1
4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / ethanol / 12 h / Reflux

2: isopropyl alcohol / 1 h / 100 °C

3: dothem / 1 h / 200 °C

4: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3 h / Reflux

With thionyl chloride; methanesulfonic acid; N,N-dimethyl-formamide; In ethanol; chloroform; dothem; isopropyl alcohol;