3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

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Chemical Name:3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide
CAS No.:1260534-44-8
Molecular Formula:C₂₂H₁₇F₃N₈O
Molecular Weight:466.425
Hs Code.:

Synonyms:3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

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Chemical Property of 3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

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Technology Process of 3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

There total 7 articles about 3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1260539-51-2
3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

: 1260534-44-8
3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:: 3-methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile; With sulfuric acid; trifluoroacetic acid; at 20 ℃; for 48h;

With sodium hydroxide; Cooling with ice;

Reference yield:

: 1260539-49-8
3-Methyl-4-{4-oxo-3-(trifluoromethyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl}benzonitrile

: 1260534-44-8
3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / chloroform / 3 h / Reflux

2.1: caesium carbonate / copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline / ethylene glycol; dimethyl sulfoxide / 2 h / 120 °C

3.1: sulfuric acid; trifluoroacetic acid / 48 h / 20 °C

3.2: Cooling with ice

With thionyl chloride; sulfuric acid; caesium carbonate; trifluoroacetic acid; copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; N,N-dimethyl-formamide; In chloroform; ethylene glycol; dimethyl sulfoxide;

Reference yield:

: 1260539-50-1
4-{4-Chloro-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}-3-methylbenzonitrile

: 1260534-44-8
3-Methyl-4-{4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline / ethylene glycol; dimethyl sulfoxide / 2 h / 120 °C

2.1: sulfuric acid; trifluoroacetic acid / 48 h / 20 °C

2.2: Cooling with ice

With sulfuric acid; caesium carbonate; trifluoroacetic acid; copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; In ethylene glycol; dimethyl sulfoxide;