[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester
CAS No.:165454-02-4
Molecular Formula:C₅₁H₇₆N₄O₁₀Si
Molecular Weight:933.271
Hs Code.:

[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Synonyms:[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

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Chemical Property of [(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

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Technology Process of [(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

There total 8 articles about [(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19542-51-9
N-benzyloxycarbonyl-L-valyl-L-phenylalanine

: 165454-02-4
[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) dicyclohexylcarbodiimide, 2) 1-hydroxybenzotriazole / 1) CH₂Cl₂, 0 deg C, 30 min, 2) CH₂Cl₂, r.t., 24 h

2: 87 percent / H₂ / 10percent Pd/C / methanol

3: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, 0.25 M N-methylmorpholine / acetonitrile / Ambient temperature

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1002/ardp.19963290602

Reference yield:

: 151920-09-1
[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

: 165454-02-4
[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / H₂ / 10percent Pd/C / methanol

2: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, 0.25 M N-methylmorpholine / acetonitrile / Ambient temperature

With 4-methyl-morpholine; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1002/ardp.19963290602

Reference yield:

: 1133-49-9
2,3,4-trimethoxybenzyl chloride

: 165454-02-4
[(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-(tert-butyl-dimethyl-silanyloxy)-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaI / acetone / 2.75 h / 15 °C

2: 85 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 1 M (Me₃Si)2NLi / tetrahydrofuran / 2.25 h / -70 °C

3: 1 M aq. LiOH / 1,2-dimethoxy-ethane; H₂O / 2 h / Ambient temperature

4: imidazole / dimethylformamide / Ambient temperature

5: aq. K₂CO₃ / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

6: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, 0.25 M N-methylmorpholine / acetonitrile / Ambient temperature

With 4-methyl-morpholine; 1H-imidazole; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/ardp.19963290602