[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester
CAS No.:151920-09-1
Molecular Formula:C₂₆H₃₃N₃O₅
Molecular Weight:467.565
Hs Code.:

Synonyms:[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

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Technology Process of [(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

There total 1 articles about [(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 19542-51-9
N-benzyloxycarbonyl-L-valyl-L-phenylalanine

: 151920-09-1
[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1) CH₂Cl₂, 0 deg C, 30 min, 2) CH₂Cl₂, r.t., 24 h;
DOI:10.1002/ardp.19963290602

Reference yield: 87.0%

: 151920-09-1
[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

: 150609-28-2
4-[((S)-valyl)-(S)-phenylalanyl]morpholine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1002/ardp.19963290602

Reference yield:

: 151920-09-1
[(S)-1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

: [(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-2-hydroxy-5-(2,3,4-trimethoxy-phenyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / H₂ / 10percent Pd/C / methanol

2: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, 0.25 M N-methylmorpholine / acetonitrile / Ambient temperature

3: 56 percent / Bu₄NF*H₂O / dimethylformamide / 20 h / Ambient temperature

With 4-methyl-morpholine; tetrabutyl ammonium fluoride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ardp.19963290602