10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

Base Information

Chemical Name:10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one
CAS No.:672341-49-0
Molecular Formula:C₂₅H₂₆N₄O₃S₂
Molecular Weight:494.638
Hs Code.:

Synonyms:10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

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Chemical Property of 10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

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Technology Process of 10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

There total 3 articles about 10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 587003-81-4
2,2-dimethyl-5-(morpholin-4-yl)-10-thioxo-1,4,10,11-tetrahydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

: 672341-49-0
10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

Guidance literature:: With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; at 20 ℃; for 5h; regioselective reaction;
DOI:10.1007/s10593-016-1887-6

Reference yield:

: C₂₇H₃₀N₄O₅S₂

: 672341-49-0
10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / 24 h / 60 - 70 °C

2: potassium hydroxide / N,N-dimethyl-formamide; ethanol; water / 5 h / 20 °C

With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1007/s10593-016-1887-6

Reference yield:

: 204775-60-0
1-amino-8,8-dimethyl-5-morpholin-4-yl-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxamide

: 672341-49-0
10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 24 h / 60 - 70 °C

2: potassium hydroxide / N,N-dimethyl-formamide; ethanol; water / 5 h / 20 °C

With potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1007/s10593-016-1887-6