10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Base Information

• Chemical Name: 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
• CAS No.: 578751-66-3
• Molecular Formula: C₂₅H₂₅ClN₄O₂S₂
• Molecular Weight: 513.084
• Mol file: 578751-66-3.mol

Synonyms:10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Chemical Property of 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

There total 4 articles about 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one (672341-49-0) → 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine (578751-66-3)

Guidance literature:

With pyridine; trichlorophosphate; for 6h; Reflux;

DOI:10.1007/s10593-016-1887-6

Reference yield:

C27H30N4O5S2 → 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine (578751-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / 24 h / 60 - 70 °C

2: potassium hydroxide / N,N-dimethyl-formamide; ethanol; water / 5 h / 20 °C

3: trichlorophosphate; pyridine / 6 h / Reflux

With pyridine; potassium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1007/s10593-016-1887-6

Reference yield:

1-amino-8,8-dimethyl-5-morpholin-4-yl-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxamide (204775-60-0) → 10-benzylsulfanyl-8-chloro-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine (578751-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 24 h / 60 - 70 °C

2: potassium hydroxide / N,N-dimethyl-formamide; ethanol; water / 5 h / 20 °C

3: trichlorophosphate; pyridine / 6 h / Reflux

With pyridine; potassium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1007/s10593-016-1887-6

upstream raw materials:

10-benzylsulfanyl-2,2-dimethyl-5-(morpholin-4-yl)-1,4-dihydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

2,2-dimethyl-5-(morpholin-4-yl)-10-thioxo-1,4,10,11-tetrahydro-2H-pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8(9H)-one

1-amino-8,8-dimethyl-5-morpholin-4-yl-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxamide

Downstream raw materials:

10-benzylthio-8-hydrazino-2,2-dimethyl-5-morpholin-4-yl-1,4-dihydro-2H-pyrano-[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

5-benzylthio-8,8-dimethyl-11-morpholin-4-yl-7,10-dihydro-8H-pyrano[4'',3'':4',5']-pyrido[3',2':4,5]thieno-[2,3-e] [1, 2, 4]triazolo[4,3-c]pyrimidine

C₂₆H₂₆N₆O₂S₂