N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

Base Information

Chemical Name:N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide
CAS No.:1378868-50-8
Molecular Formula:C₁₆H₁₆BrFN₂O₂S
Molecular Weight:399.284
Hs Code.:

Synonyms:N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

There total 5 articles about N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 127425-73-4
1-bromo-4-(bromomethyl)-2-fluorobenzene

: 1378869-01-2
N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

: 1378868-50-8
N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 1378868-50-8
N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / methanol / 20 °C / 2585.81 Torr

3: triethylamine / dichloromethane / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 40 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With potassium fluoride; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1365763-14-9
4-cyclopropyl-3-nitropyridine

: 1378868-50-8
N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / methanol / 20 °C / 2585.81 Torr

2: triethylamine / dichloromethane / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 40 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;