1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

Base Information

Chemical Name:1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium
CAS No.:1378868-51-9
Molecular Formula:C₁₆H₁₈BrFN₃O₂S
Molecular Weight:415.306
Hs Code.:

Synonyms:1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

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Chemical Property of 1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

Chemical Property:

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Technology Process of 1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

There total 7 articles about 1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1378868-50-8
N-(4-bromo-3-fluorobenzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide

: 36016-40-7
mesitylenesulfonylhydroxylamine

: 1378868-51-9
1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

Guidance literature:: at 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 1378868-51-9
1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

Guidance literature:: Multi-step reaction with 6 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / methanol / 20 °C / 2585.81 Torr

3: triethylamine / dichloromethane / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 40 °C

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

6: 72 h / 20 °C / Inert atmosphere

With potassium fluoride; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1365763-14-9
4-cyclopropyl-3-nitropyridine

: 1378868-51-9
1-amino-3-(N-(4-bromo-3-fluorobenzyl)methylsulfonamido)-4-cyclopropylpyridinium

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium on activated charcoal / methanol / 20 °C / 2585.81 Torr

2: triethylamine / dichloromethane / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 40 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

5: 72 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;