p-(Salicylideneamino)benzoic acid

Base Information

• Chemical Name: p-(Salicylideneamino)benzoic acid
• CAS No.: 788-24-9
• Molecular Formula: C14H11NO3
• Molecular Weight: 241.246
• European Community (EC) Number: 685-021-9
• NSC Number: 100884
• DSSTox Substance ID: DTXSID101291043
• Nikkaji Number: J87.213J,J2.566.271G
• ChEMBL ID: CHEMBL3939899
• Mol file: 788-24-9.mol

Synonyms:p-(Salicylideneamino)benzoic acid;788-24-9;915070-60-9;Benzoic acid, p-(salicylideneamino)-;4-[(2-hydroxyphenyl)methylideneamino]benzoic acid;BRN 2215393;N-salicylidene-4-carboxyaniline;p-((o-Hydroxybenzylidene)amino)benzoic acid;CHEMBL3939899;Benzoic acid, p-((o-hydroxybenzylidene)amino)-;(E)-4-((2-hydroxybenzylidene)amino)benzoic acid;MFCD00187093;Benzoic acid, 4-(((2-hydroxyphenyl)methylene)amino)-;4-[(6-oxo-1-cyclohexa-2,4-dienylidene)methylamino]benzoic acid;4-[(2-Hydroxy-benzylidene)-amino]-benzoic acid;4-14-00-01185 (Beilstein Handbook Reference);4-{[(E)-(2-hydroxyphenyl)methylidene]amino}benzoic acid;4-[(E)-[(2-HYDROXYPHENYL)METHYLIDENE]AMINO]BENZOIC ACID;4-((2-HYDROXY-BENZYLIDENE)-AMINO)-BENZOIC ACID;NCIOpen2_007011;SCHEMBL5281255;4-(Salicylideneamino)benzoic acid;CHEBI:144335;DTXSID101291043;BDBM50212062;N-(4-Carboxyphenyl)salicylideneimine;NSC100884;STK022029;AKOS000269496;NSC 100884;NSC-100884;LS-37539;4-((2-Hydroxybenzylidene)amino)benzoic acid;CS-0326393;4-[[(E)-2-Hydroxybenzylidene]amino]benzoic acid;SR-01000108076;SR-01000108076-1;4-{[(1E)-(2-hydroxyphenyl)methylene]amino}benzoic acid;F0777-0813;4-([(E)-(2-Hydroxyphenyl)methylidene]amino)benzoic acid #

Chemical Property of p-(Salicylideneamino)benzoic acid

Chemical Property:

• Vapor Pressure: 3.12E-09mmHg at 25°C
• Boiling Point: 459.3°C at 760 mmHg
• Flash Point: 231.6°C
• Density: 1.447g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 241.07389321
• Heavy Atom Count: 18
• Complexity: 308

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NC2=CC=C(C=C2)C(=O)O)O

Technology Process of p-(Salicylideneamino)benzoic acid

There total 7 articles about p-(Salicylideneamino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

salicylaldehyde (90-02-8) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-[(2-hydroxybenzylidene)amino]benzoic acid (788-24-9)

Guidance literature:

In neat (no solvent, solid phase); at 20 ℃; for 0.3h;

DOI:10.14233/ajchem.2021.23009

Reference yield:

salicylaldehyde (90-02-8) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-(2-hydroxybenzylideneamino)benzoic acid (788-24-9)

Guidance literature:

In ethanol; at 20 ℃; for 5h;

DOI:10.1016/j.chemphys.2014.10.007

Reference yield:

chloro-trimethyl-silane (75-77-4) + salicylaldehyde (90-02-8) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-[(2-hydroxybenzylidene)amino]benzoic acid (788-24-9)

Guidance literature:

With triethylamine; In dichloromethane; benzene;

upstream raw materials:

salicylaldehyde

4-amino-benzoic acid

chloro-trimethyl-silane

2-methyl-benzyl alcohol

Downstream raw materials:

C₂₆H₂₀NO₅P

4-(2-(2-hydroxyphenyl)-4,5-diphenyl-1H-imidazol-1-yl)benzoic acid