methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

Base Information

Chemical Name:methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate
CAS No.:1416053-04-7
Molecular Formula:C₂₄H₁₆N₂O₄
Molecular Weight:396.402
Hs Code.:

Synonyms:methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

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Chemical Property of methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

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Technology Process of methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

There total 6 articles about methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1416052-91-9
methyl 4-(2-iodobenzamido)biphenyl-3-carboxylate

: 105-34-0
methyl 2-cyanoacetate

: 1416053-04-7
methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 85 ℃; for 3h;
DOI:10.1039/c2cc37070k

Reference yield:

: 77317-55-6
methyl 2-amino-5-iodobenzoate

: 1416053-04-7
methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol / 8 h / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 3 h / 85 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2cc37070k

Reference yield:

: 609-67-6
2-Iodobenzoyl chloride

: 1416053-04-7
methyl-5,12-dioxo-3-phenyl-6,12-dihydro-5H-isoquinolino[2,3-a]quinazoline-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 3 h / 85 °C

With copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c2cc37070k