N-(Benzyloxycarbonyl)glycine tert-butyl ester

Base Information

• Chemical Name: N-(Benzyloxycarbonyl)glycine tert-butyl ester
• CAS No.: 16881-32-6
• Molecular Formula: C14H19NO4
• Molecular Weight: 265.309
• Mol file: 16881-32-6.mol

Synonyms:

Chemical Property of N-(Benzyloxycarbonyl)glycine tert-butyl ester

Chemical Property:

• PSA: 68.12000
• LogP: 2.45890

Purity/Quality:

98%min ^*data from raw suppliers

BENZYLOXYCARBONYLAMINO-ACETIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(Benzyloxycarbonyl)glycine tert-butyl ester

There total 13 articles about N-(Benzyloxycarbonyl)glycine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

methyl N-benzyloxycarbonylglycinate (1212-53-9) + tert-butyl alcohol (75-65-0) → tert-butyl N-(benzyloxycarbonyl)glycinate (16881-32-6)

Guidance literature:

Zn₄O (OCOCF₃)₆(CF₃COOH)_n ; In di-isopropyl ether; for 18h; Product distribution / selectivity; Inert atmosphere; Reflux;

Reference yield: 90.0%

Succinimide (123-56-8,89963-74-6) + Glycine tert-butyl ester (6456-74-2) → tert-butyl N-(benzyloxycarbonyl)glycinate (16881-32-6)

Guidance literature:

In dichloromethane;

Reference yield: 90.0%

glycine tert-butyl ester hydrochloride (27532-96-3) + benzyl chloroformate (501-53-1,94274-21-2) → tert-butyl N-(benzyloxycarbonyl)glycinate (16881-32-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1002/1099-0690(200108)2001:16<3089::AID-EJOC3089>3.0.CO;2-L

upstream raw materials:

tert-Butyl iodide

N-(Benzyloxycarbonyl)glycine

isobutene

Glycine tert-butyl ester

Downstream raw materials:

mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid

N-(Benzyloxycarbonyl)glycine

(2-amino-2-methyl-3,3-diphenyl-propionylamino)-acetic acid tert-butyl ester

[2-(2-amino-acetylamino)-2-methyl-3,3-diphenyl-propionylamino]-acetic acid tert-butyl ester

Refernces

• 1、 -. "TRANSESTERIFICATION REACTION BY MEANS OF IRON CATALYST". Paragraph 0134; 0135; 0142; 0143. . Retrieved 2017/10/10.
• 2、 -. "ZINC CLUSTER". Page/Page column 4. . Retrieved 2012/07/14.