4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Base Information

Chemical Name:4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene
CAS No.:141667-54-1
Molecular Formula:C₁₅H₁₇NO₅S
Molecular Weight:323.37
Hs Code.:

Synonyms:4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

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Chemical Property of 4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

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Technology Process of 4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

There total 5 articles about 4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 141667-41-6
4-<(tert-butyldimethylsilyl)oxy>-5-endo-(hydroxymethyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

: 141667-54-1
4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h; Ambient temperature;
DOI:10.1021/jo00041a010

Reference yield:

: 16867-04-2
dihydroxypyridine

: 141667-54-1
4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / imidazole / dimethylformamide / 3 h

2: 1) MeLi / 1) Et₂O, 2) Et₂O

3: 70 percent / BHT / CH₂Cl₂ / 148 h / 90 °C

4: 100 percent / NaBH₄ / methanol / 0.25 h / Ambient temperature

5: 60 percent / n-Bu₄NF / tetrahydrofuran / 0.33 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; methyllithium; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00041a010

Reference yield:

: 141667-58-5
3-<(tert-butyldimethylsilyl)oxy>-2-pyridone

: 141667-54-1
4-hydroxy-5-endo-(hydroxymethyl)-2-(4'-methylbenzesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 1) MeLi / 1) Et₂O, 2) Et₂O

2: 70 percent / BHT / CH₂Cl₂ / 148 h / 90 °C

3: 100 percent / NaBH₄ / methanol / 0.25 h / Ambient temperature

4: 60 percent / n-Bu₄NF / tetrahydrofuran / 0.33 h / Ambient temperature

With sodium tetrahydroborate; 2,6-di-tert-butyl-4-methyl-phenol; tetrabutyl ammonium fluoride; methyllithium; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00041a010