2,3-Dihydroxypyridine

Base Information

• Chemical Name: 2,3-Dihydroxypyridine
• CAS No.: 16867-04-2
• Deprecated CAS: 119764-03-3,13466-42-7,13466-42-7
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• Hs Code.: 29333999
• European Community (EC) Number: 240-887-3
• NSC Number: 49272
• UNII: 7HY4BCJ130
• DSSTox Substance ID: DTXSID0051782
• Nikkaji Number: J141.791F
• Wikidata: Q27225138
• Metabolomics Workbench ID: 71536
• ChEMBL ID: CHEMBL287899
• Mol file: 16867-04-2.mol

Synonyms:2,3-dihydroxypyridine;3-hydroxy-2-pyridinone

Chemical Property of 2,3-Dihydroxypyridine

Chemical Property:

• Appearance/Colour: khaki to grey or brown crystalline powder
• Vapor Pressure: 1.35E-07mmHg at 25°C
• Melting Point: 245 °C (dec.)(lit.)
• Refractive Index: 1.593
• Boiling Point: 387.2 °C at 760 mmHg
• PKA: 9.00±0.10(Predicted)
• Flash Point: 188 °C
• PSA: 53.35000
• Density: 1.379 g/cm³
• LogP: 0.49280
• Storage Temp.: Store below +30°C.
• Water Solubility.: Soluble in water.
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.032028402
• Heavy Atom Count: 8
• Complexity: 169

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-2-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-40
• Safety Statements: 26-36-37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CNC(=O)C(=C1)O
• Uses: 2,3-Dihydroxypyridine(DHP) was used in the synthesis of DHP loaded amberlite XAD-2 via azo coupler. It was used in the synthesis of new macromolecular chelators by loading DHP on cellulose via linkers -NH-CH2-CH2-NH-SO2-C6H4-N=N- and -SO2-C6H4-N=N.

Technology Process of 2,3-Dihydroxypyridine

There total 18 articles about 2,3-Dihydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

3-HYDROXYPYRIDINE (109-00-2) → dihydroxypyridine (16867-04-2) + 3,4-dihydroxypyridine (10182-48-6)

Guidance literature:

In various solvent(s); at 28 ℃; for 48h; the root-form rhodococcus opacus (the M form) bacteria;

DOI:10.1007/BF00531557

Reference yield: 9.0%

3-HYDROXYPYRIDINE (109-00-2) → 3-hydroxypyridine N-oxide (6602-28-4) + dihydroxypyridine (16867-04-2) + 3,4-dihydroxypyridine (10182-48-6) + 1,2-dihydro-2,3-dihydroxypyridine

Guidance literature:

In various solvent(s); at 28 ℃; for 48h; pseudomonas fluorescens PfE₁ bacteria;

DOI:10.1007/BF00531557

Reference yield:

2-bromo-3-ethoxypyridine (89694-54-2) → dihydroxypyridine (16867-04-2) + 2-chloro-3-hydroxypyridine (6636-78-8)

Guidance literature:

With hydrogenchloride; water; at 160 ℃; unter Druck;

upstream raw materials:

furfural

(furan-2-yl)methylene diacetate

2-methoxy-3-hydroxypyridine

2-bromo-3-ethoxypyridine

Downstream raw materials:

3-hydroxypiperidin-2-one

3-benzyloxy-2-hydroxypyridine

1-benzyl-3-benzyloxy-2-(1H)pyridone

1,4-benzodioxino<2,3-b>pyridine