[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester
CAS No.:1313525-75-5
Molecular Formula:C₁₇H₂₁BrFN₃O₃
Molecular Weight:414.274
Hs Code.:

Synonyms:[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

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Chemical Property of [6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

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Technology Process of [6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

There total 9 articles about [6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1313525-74-4
5-amino-3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

: 1313525-75-5
[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1313525-75-5
[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium hydroxide; ammonium chloride / water / 20 °C

1.2: Reflux

2.1: hydrogenchloride; water / Reflux

3.1: sodium hydroxide / water

4.1: thionyl chloride / -10 °C

4.2: 18 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C

6.1: ethanol / 1.5 h / 50 °C

7.1: Lawessons reagent / tetrahydrofuran / 2 h / 50 °C

8.1: tert.-butylhydroperoxide; ammonium hydroxide / water; tetrahydrofuran; methanol / 40 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

With Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; thionyl chloride; water; ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1266784-18-2
rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester

: 1313525-75-5
[6-(5-bromo-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C

2: ethanol / 1.5 h / 50 °C

3: Lawessons reagent / tetrahydrofuran / 2 h / 50 °C

4: tert.-butylhydroperoxide; ammonium hydroxide / water; tetrahydrofuran; methanol / 40 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran

With Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;