2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER
• CAS No.: 1266784-18-2
• Molecular Formula: C10H11BrFNO2
• Molecular Weight: 276.105
• Mol file: 1266784-18-2.mol

Synonyms:2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER;(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methylester

Chemical Property of 2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER

Chemical Property:

• PSA: 52.32000
• LogP: 2.63540

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER

There total 11 articles about 2-AMINO-2-(5-BROMO-2-FLUOROPHENYL)PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid (1266784-23-9) → rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester (1266784-18-2)

Guidance literature:

With sulfuric acid; for 48h;

DOI:10.1016/j.bmcl.2011.10.050

Reference yield: 87.0%

(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid (1266784-23-9) → rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester (1266784-18-2)

Guidance literature:

With sulfuric acid; In methanol; Reflux;

DOI:10.1021/acs.jmedchem.5b01101

Reference yield: 43.0%

methanol (67-56-1) + 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride (1374765-83-9) → rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester (1266784-18-2)

Guidance literature:

methanol; 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride; With hydrogenchloride; In water; for 48h; Reflux;

With sodium hydrogencarbonate; In water; pH=9;

upstream raw materials:

5-bromo-2-fluoro-benzoic acid

1-(5-bromo-2-fluorophenyl)ethan-1-one

5-bromo-2-fluoro-N-methoxy-N-methylbenzamide

methanol

Downstream raw materials:

N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-acrylamide

(2RS)-bromo-N-[(RS)-1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-methyl-ethyl]-3-phenyl-propionamide

3-(5-bromo-2-fluorophenyl)-1,3-dimethylpiperazine-2,5-dione

3-(5-bromo-2-fluorophenyl)-1,3-dimethyl-5-thioxopiperazin-2-one