Technology Process of [6-(5-amino-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester
There total 11 articles about [6-(5-amino-2-fluorophenyl)-4,6-dimethyl-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl]carbamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: ammonium hydroxide; ammonium chloride / water / 20 °C
1.2: Reflux
2.1: hydrogenchloride; water / Reflux
3.1: sodium hydroxide / water
4.1: thionyl chloride / -10 °C
4.2: 18 h / Reflux
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C
6.1: ethanol / 1.5 h / 50 °C
7.1: Lawessons reagent / tetrahydrofuran / 2 h / 50 °C
8.1: tert.-butylhydroperoxide; ammonium hydroxide / water; tetrahydrofuran; methanol / 40 °C
9.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran
10.1: sodium azide / copper(l) iodide; sodium L-ascorbate; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane / ethanol; water / 2 h / 45 °C / Inert atmosphere
11.1: hydrogen / palladium 10% on activated carbon / ethanol
With
Lawessons reagent; hydrogenchloride; tert.-butylhydroperoxide; ammonium hydroxide; thionyl chloride; sodium azide; water; hydrogen; ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
copper(l) iodide; palladium 10% on activated carbon; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane; sodium L-ascorbate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: thionyl chloride / -10 °C
1.2: 18 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / -5 °C
3.1: ethanol / 1.5 h / 50 °C
4.1: Lawessons reagent / tetrahydrofuran / 2 h / 50 °C
5.1: tert.-butylhydroperoxide; ammonium hydroxide / water; tetrahydrofuran; methanol / 40 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran
7.1: sodium azide / copper(l) iodide; sodium L-ascorbate; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane / ethanol; water / 2 h / 45 °C / Inert atmosphere
8.1: hydrogen / palladium 10% on activated carbon / ethanol
With
Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; thionyl chloride; sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine;
copper(l) iodide; palladium 10% on activated carbon; (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane; sodium L-ascorbate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
