(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Base Information

Chemical Name:(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate
CAS No.:1396007-54-7
Molecular Formula:C₂₈H₂₆N₈O₂
Molecular Weight:506.567
Hs Code.:

Synonyms:(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

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Chemical Property of (R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

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Technology Process of (R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

There total 8 articles about (R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1396007-97-8
(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

: 1396007-54-7
(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 20 - 100 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1396007-96-7
{5-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3H-[1,2,3]triazol-4-yl}-carbamic acid (R)-1-phenyl-ethyl ester

: 124276-67-1
1-(4-bromophenyl)cyclopropanecarbonitrile

: 1396007-54-7
(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / water; toluene / 3 h / 105 °C / Inert atmosphere; Sealed tube

2: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 15 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; trimethylsilylazide; palladium diacetate; di(n-butyl)tin oxide; In water; toluene; 1: |Suzuki Coupling;
DOI:10.1021/jm301022v

Reference yield:

: 1396007-93-4
[3-(4-bromo-phenyl)-5-methyl-3H-[1,2,3]triazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-54-7
(R)-1-phenyl-ethyl 1-(4'-(1-(1H-tetrazol-5-yl)cyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3.5 h / 80 °C / Inert atmosphere

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 3 h / 20 - 105 °C / Inert atmosphere

3: di(n-butyl)tin oxide; trimethylsilylazide / toluene / 15 h / 20 - 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; trimethylsilylazide; potassium acetate; palladium diacetate; di(n-butyl)tin oxide; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;