(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Base Information

Chemical Name:(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate
CAS No.:1396007-97-8
Molecular Formula:C₂₈H₂₅N₅O₂
Molecular Weight:463.539
Hs Code.:

Synonyms:(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

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Chemical Property of (R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

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Technology Process of (R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

There total 7 articles about (R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1396007-96-7
{5-methyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3H-[1,2,3]triazol-4-yl}-carbamic acid (R)-1-phenyl-ethyl ester

: 124276-67-1
1-(4-bromophenyl)cyclopropanecarbonitrile

: 1396007-97-8
(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; toluene; at 20 - 105 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1396007-92-3
3-(4-bromo-phenyl)-5-methyl-3H-[1,2,3]triazole-4-carboxylic acid

: 1396007-97-8
(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3.5 h / 80 °C / Inert atmosphere

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 3 h / 20 - 105 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; diphenyl phosphoryl azide; potassium acetate; palladium diacetate; triethylamine; In 1,4-dioxane; water; toluene; 3: |Suzuki Coupling;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1396007-97-8
(R)-1-phenyl-ethyl 1-(4'-(1-cyanocyclopropyl)biphenyl-4-yl)-4-methyl-1H-1,2,3-triazol-5-yl carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 22 h / 50 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 3 h / 20 - 105 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydroxide; In water; toluene; 2: |Suzuki Coupling;