6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester
• CAS No.: 129363-86-6
• Molecular Formula: C₁₄H₁₂O₄S
• Molecular Weight: 276.313
• Mol file: 129363-86-6.mol

Synonyms:6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester

Chemical Property of 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester

There total 4 articles about 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-ethyl 6-tert-butyl 2-(dimethylamino)-5-(phenylthio)-2,4-hexadienedioate (129363-77-5) → 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester (129363-86-6)

Guidance literature:

With hydrogenchloride; acetic acid; In ethanol; for 0.5h; Ambient temperature;

DOI:10.1021/jm00172a010

Reference yield:

ethyl 4-(dimethylamino)-2-oxo-3-butenoate (67751-14-8) → 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester (129363-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) triethyloxonium tetrafluoroborate / 1.) CH₂Cl₂, RT, 5 h, 2.) Et₂O, 5 deg C, 15 h

2: 61 percent / n-BuLi / ethanol / 2.33 h / Ambient temperature

3: 62 percent / 1 N HCl, AcOH / ethanol / 0.5 h / Ambient temperature

With hydrogenchloride; n-butyllithium; triethyloxonium fluoroborate; acetic acid; In ethanol;

DOI:10.1021/jm00172a010

Reference yield:

tert-butyl (phenylthio)acetate (63006-68-8) → 6-Oxo-5-phenylsulfanyl-6H-pyran-2-carboxylic acid ethyl ester (129363-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / n-BuLi / ethanol / 2.33 h / Ambient temperature

2: 62 percent / 1 N HCl, AcOH / ethanol / 0.5 h / Ambient temperature

With hydrogenchloride; n-butyllithium; acetic acid; In ethanol;

DOI:10.1021/jm00172a010

upstream raw materials:

1-ethyl 6-tert-butyl 2-(dimethylamino)-5-(phenylthio)-2,4-hexadienedioate

ethyl 4-(dimethylamino)-2-oxo-3-butenoate

tert-butyl (phenylthio)acetate