Technology Process of tert-butyl 4-phenyl-3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate
There total 9 articles about tert-butyl 4-phenyl-3-(piperidine-1-carbonyl)-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(tert-butoxycarbonyl)-4-phenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylic acid;
With
4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
piperidine;
In
N,N-dimethyl-formamide;
for 12h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
2.1: triethylamine / dichloromethane / 0 - 20 °C
3.1: hydrogenchloride; water / 0 - 130 °C
4.1: triethylamine / dichloromethane / 2 h / 20 °C
5.1: lithium hydroxide monohydrate; water / ethanol
6.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
6.2: 12 h
With
4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / -78 - 20 °C
1.2: 1 h / -78 °C
2.1: L-Selectride / tetrahydrofuran / -78 - 20 °C
3.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux
4.1: triethylamine / dichloromethane / 0 - 20 °C
5.1: hydrogenchloride; water / 0 - 130 °C
6.1: triethylamine / dichloromethane / 2 h / 20 °C
7.1: lithium hydroxide monohydrate; water / ethanol
8.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 20 °C
8.2: 12 h
With
4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; trimethylsilyl trifluoromethanesulfonate; water; L-Selectride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
