ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

Base Information

Chemical Name:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate
CAS No.:1402145-32-7
Molecular Formula:C₂₄H₂₁F₃N₂O₄
Molecular Weight:458.437
Hs Code.:

Synonyms:ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

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Chemical Property of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

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Technology Process of ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

There total 4 articles about ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1402145-31-6
1-benzyl-4-bromo-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazole

: 4755-77-5
Ethyl oxalyl chloride

: 1402145-32-7
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

Guidance literature:: 1-benzyl-4-bromo-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazole; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 ℃; Inert atmosphere;

Ethyl oxalyl chloride; at -20 ℃; for 1h;

Reference yield:

: 119-84-6,1341-36-2
C₆H₄(CH₂CH₂C(O)O)

: 1402145-32-7
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc; acetic acid / 15 h / 100 °C

2.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

2.2: 2 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

3.2: 3 h / 20 °C

4.1: acetonitrile / 16 h / Reflux

5.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

6.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

6.2: 1 h / -20 °C

With N-Bromosuccinimide; isopropylmagnesium chloride; sodium hydride; acetic acid; Ethyl oxalyl chloride; zinc; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 493-08-3
chromane

: 1402145-32-7
ethyl 2-[1-benzyl-5-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2-oxoacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Ethyl oxalyl chloride / dichloromethane / -10 °C

1.2: 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 30 h / -5 - 0 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: acetonitrile / 16 h / Reflux

4.1: N-Bromosuccinimide / acetonitrile / 0.75 h / Reflux

5.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

5.2: 1 h / -20 °C

With N-Bromosuccinimide; isopropylmagnesium chloride; sodium hydride; Ethyl oxalyl chloride; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;