cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

Base Information

Chemical Name:cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol
CAS No.:1253197-19-1
Molecular Formula:C₂₃H₂₉NO₂
Molecular Weight:351.489
Hs Code.:

Synonyms:cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

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Chemical Property of cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

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Technology Process of cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

There total 7 articles about cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4894-75-1
1-phenyl-4-cyclohexanone

: 1229622-03-0
7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol

: 1253197-18-0
trans-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-19-1
cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

Guidance literature:: With sodium tris(acetoxy)borohydride; potassium carbonate; In acetic acid; 1,2-dichloro-ethane; at 20 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/cmdc.201000005

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1253197-18-0
trans-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-19-1
cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; methanol / 2 h / 20 °C

3: methanol; magnesium / 5 h / Reflux

4: sodium tris(acetoxy)borohydride; acetic acid / 3 h / 20 °C

With methanol; sodium tetrahydroborate; phosphorus pentoxide; sodium tris(acetoxy)borohydride; magnesium; acetic acid; In 1,2-dichloro-ethane;

Reference yield:

: 64880-89-3
N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide

: 1253197-18-0
trans-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-19-1
cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 20 h / Reflux

2: sodium hydroxide; water / ethanol / 5 h / Reflux

3: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

4: sodium tetrahydroborate; methanol / 2 h / 20 °C

5: methanol; magnesium / 5 h / Reflux

6: sodium tris(acetoxy)borohydride; acetic acid / 3 h / 20 °C

With methanol; sodium tetrahydroborate; phosphorus pentoxide; water; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium; acetic acid; sodium hydroxide; In ethanol; 1,2-dichloro-ethane; acetone;