64880-89-3Relevant academic research and scientific papers
Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation
Henry, Martyn C.,Senn, Hans Martin,Sutherland, Andrew
, p. 346 - 364 (2019/01/08)
A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.
NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES
-
Paragraph 145, (2017/03/21)
The present invention provides novel means and methods for treatment auf immunemediated inflammatory diseases.
NR2B-SELECTIVE NMDA-RECEPTOR ANTAGONISTS
-
Page/Page column 39-40, (2010/11/05)
The present invention relates to compounds according to general formula (I) and pharmaceutical compositions comprising compounds according to general formula (I).
Design, synthesis, and biological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagonists
Tewes, Bastian,Frehland, Bastian,Schepmann, Dirk,Schmidtke, Kai-Uwe,Winckler, Thomas,Wuensch, Bernhard
scheme or table, p. 687 - 695 (2010/12/29)
Cleavage and reconstitution of a bond in the piperidine ring of ifenprodil (1) leads to 7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols, a novel class of NR2B-selective NMDA receptor antagonists. The secondary amine 7-methoxy-2,3,4,5-tetrahydro-1H-3-be
Catalytic N-sulfonyliminium ion-mediated cyclizations to α-vinyl-substituted isoquinolines and β-carbolines and applications in metathesis
Kinderman, Sape S.,Wekking, Monique M. T.,Van Maarseveen, Jan H.,Schoemaker, Hans E.,Hiemstra, Henk,Rutjes, Floris P. J. T.
, p. 5519 - 5527 (2007/10/03)
Catalytic Sn(OTf)2-induced cyclization of linear, aryl-containing allylic N,O-acetals produced vinyl-substituted tetrahydroisoquinolines and tetrahydro-1H-β-carbolines. The usefulness of the vinyl moiety in the resulting products was demonstrated via the synthesis of various key building blocks for alkaloid structures. The α-vinyl moiety was utilized in a [2,3] sigmatropic rearrangement, in ring-closing metathesis and a cross-metathesis-based synthesis of vincantril, an antianoxia agent, and a synthetic member of the vincamine type natural products.
THALLIUM IN ORGANIC SYNTHESIS. 67. INTRAMOLECULAR CAPTURE OF AROMATIC RADICAL CATIONS BY AN N-TOSYL GROUP
McKillop, Alexander,Davies, Huw M. L.,Taylor, Edward C.
, p. 267 - 282 (2007/10/02)
Radical cations, generated by oxidation of electron-rich arenes by thallium(III) tris(trifluoroacetate), undergo rapid intramolecular capture by an N-tosyl group.
