2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione

Base Information

• Chemical Name: 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione
• CAS No.: 272449-71-5
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.197
• Mol file: 272449-71-5.mol

Synonyms:2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione

There total 1 articles about 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride (6118-51-0) + Propargylamine (2450-71-7) → 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione (272449-71-5)

Guidance literature:

In methanol; at 0 - 65 ℃;

DOI:10.1021/ma100779q

Reference yield: 88.0%

2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione (272449-71-5) → N-propargylmaleimide (209395-32-4)

Guidance literature:

at 165 - 175 ℃;

DOI:10.1080/00397910008087165

Reference yield: 81.0%

5-((4-azidobenzoyl)amino)-N,N'-bis(6-(octanoylamino)pyridine-2-yl)isophthalamide (823226-61-5) + 2-(2-propynyl)-3α,4,7,7α-tetrahydro-4,7-epoxy-1H-isoindole-1,3(2H)-dione (272449-71-5) → 5-{4-[4-((exo-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximido)methyl)[1,2,3]triazol-1-yl]benzoylamino}-N,N'-bis(6-(octanoylamino)pyridine-2-yl)isophthalamide

Guidance literature:

With bromotris(triphenylphosphine)copper(I); N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1021/ma0480087

upstream raw materials:

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

Propargylamine

Downstream raw materials:

N-propargylmaleimide