N-(1-oxiranyl-3-phenyl-propyl)-butyramide

Base Information

• Chemical Name: N-(1-oxiranyl-3-phenyl-propyl)-butyramide
• CAS No.: 380848-37-3
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 380848-37-3.mol

Synonyms:N-(1-oxiranyl-3-phenyl-propyl)-butyramide

Chemical Property of N-(1-oxiranyl-3-phenyl-propyl)-butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-oxiranyl-3-phenyl-propyl)-butyramide

There total 5 articles about N-(1-oxiranyl-3-phenyl-propyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(1-phenethyl-allyl)-butyramide (380848-27-1) → N-(1-oxiranyl-3-phenyl-propyl)-butyramide (380848-37-3)

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; at 20 ℃;

DOI:10.1021/ol0166496

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → N-(1-oxiranyl-3-phenyl-propyl)-butyramide (380848-37-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Ti(OEt)4 / CH₂Cl₂; propan-2-ol / 20 °C

2.1: Mg / I₂ / diethyl ether / Heating

2.2: diethyl ether; CH₂Cl₂ / 20 h / -48 - 20 °C

3.1: dioxane; methanol / 0.5 h

4.1: N-methyl morpholine; isobutyl chloroformate / tetrahydrofuran / 0.75 h / -20 °C

4.2: 4-hydroxy-3-nitrobenzophenone resin; pyridine / tetrahydrofuran; dimethylformamide / 12 h

4.3: 100 percent / CH₂Cl₂ / 24 h

5.1: 100 percent / dimethyldioxirane / acetone / 20 °C

With 4-methyl-morpholine; titanium(IV) tetraethanolate; 3,3-dimethyldioxirane; magnesium; isobutyl chloroformate; iodine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; isopropyl alcohol; acetone;

DOI:10.1021/ol0166496

Reference yield:

2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide (854497-57-7) → N-(1-oxiranyl-3-phenyl-propyl)-butyramide (380848-37-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Mg / I₂ / diethyl ether / Heating

1.2: diethyl ether; CH₂Cl₂ / 20 h / -48 - 20 °C

2.1: dioxane; methanol / 0.5 h

3.1: N-methyl morpholine; isobutyl chloroformate / tetrahydrofuran / 0.75 h / -20 °C

3.2: 4-hydroxy-3-nitrobenzophenone resin; pyridine / tetrahydrofuran; dimethylformamide / 12 h

3.3: 100 percent / CH₂Cl₂ / 24 h

4.1: 100 percent / dimethyldioxirane / acetone / 20 °C

With 4-methyl-morpholine; 3,3-dimethyldioxirane; magnesium; isobutyl chloroformate; iodine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; acetone;

DOI:10.1021/ol0166496

upstream raw materials:

N-(1-phenethyl-allyl)-butyramide

3-phenyl-propionaldehyde

(S)-5-phenylpent-1-en-3-amine

2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide