2-(1H-Benzimidazol-2-YL)-3-(1,3-diphenyl-1H-pyrazol-4-YL)acrylonitrile

Base Information

• Chemical Name: 2-(1H-Benzimidazol-2-YL)-3-(1,3-diphenyl-1H-pyrazol-4-YL)acrylonitrile
• CAS No.: 391659-80-6
• Molecular Formula: C₂₅H₁₇N₅
• Molecular Weight: 387.443
• European Community (EC) Number: 645-765-7
• Wikidata: Q76313254

Synonyms:AKOS001030621;2-(1H-BENZIMIDAZOL-2-YL)-3-(1,3-DIPHENYL-1H-PYRAZOL-4-YL)ACRYLONITRILE

Chemical Property of 2-(1H-Benzimidazol-2-YL)-3-(1,3-diphenyl-1H-pyrazol-4-YL)acrylonitrile

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 387.14839556
• Heavy Atom Count: 30
• Complexity: 654

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN(C=C2C=C(C#N)C3=NC4=CC=CC=C4N3)C5=CC=CC=C5
• Isomeric SMILES: C1=CC=C(C=C1)C2=NN(C=C2/C=C(\C#N)/C3=NC4=CC=CC=C4N3)C5=CC=CC=C5

Technology Process of 2-(1H-Benzimidazol-2-YL)-3-(1,3-diphenyl-1H-pyrazol-4-YL)acrylonitrile

There total 10 articles about 2-(1H-Benzimidazol-2-YL)-3-(1,3-diphenyl-1H-pyrazol-4-YL)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1H-benzimidazol-2-acetonitrile (4414-88-4) + 1,3-diphenyl-4-formylpyrazole (21487-45-6) → 2-(1H-benzo[d]imidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile (391659-80-6)

Guidance literature:

With triethylamine; In ethanol; Reflux;

DOI:10.1055/s-0031-1295483

Reference yield:

3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile + 1,2-diamino-benzene (95-54-5) → 2-(1H-benzo[d]imidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile (391659-80-6) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4)

Guidance literature:

at 180 - 190 ℃; for 1h;

DOI:10.1080/00397911.2021.1879152

Reference yield:

3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile + 1,2-diamino-benzene (95-54-5) → 2-(1H-benzo[d]imidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile (391659-80-6) + N-(2-aminophenyl)-2-(2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylamido)benzamide + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4)

Guidance literature:

With sodium acetate; acetic acid; for 1h; Reflux;

DOI:10.1080/00397911.2021.1879152

upstream raw materials:

1H-benzimidazol-2-acetonitrile

1,3-diphenyl-4-formylpyrazole

N-(1-phenylethylidene)phenylhydrazine

acetophenone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 391659-80-6 2-(1H-benzo[d]imidazol-2-yl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)acrylonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send