(2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime

Base Information

• Chemical Name: (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime
• CAS No.: 74955-00-3
• Molecular Formula: C₁₉H₂₁ClN₂OS₂
• Molecular Weight: 392.974
• Mol file: 74955-00-3.mol

Synonyms:(2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime

Chemical Property of (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime

There total 2 articles about (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-hydroxybenzimidoyl chloride (29568-74-9) → (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime (74955-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran

2: 1.) n-BuLi / 1.) TMEDA, -78 deg C, 2.) THF, -78 deg C, overnight

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)77826-9

Reference yield:

4-(N,N'-dimethylamino)phenyl-1,3-dithiane (24588-75-8) + 2-chlorobenzonitrile oxide (49660-38-0) → (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime (74955-00-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) TMEDA, -78 deg C, 2.) THF, -78 deg C, overnight;

DOI:10.1016/S0040-4039(00)77826-9

Reference yield: 95.5%

(2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime (74955-00-3) → 1-(2-Chloro-phenyl)-2-(4-dimethylamino-phenyl)-ethane-1,2-dione (68289-15-6)

Guidance literature:

With formaldehyd; trifluoroacetic acid; In chloroform; for 72h; Ambient temperature;

DOI:10.1016/S0040-4039(00)77826-9

upstream raw materials:

4-(N,N'-dimethylamino)phenyl-1,3-dithiane

2-chlorobenzonitrile oxide

2-chloro-N-hydroxybenzimidoyl chloride

Downstream raw materials:

1-(2-Chloro-phenyl)-2-(4-dimethylamino-phenyl)-ethane-1,2-dione