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Usage

Uses

Used in Organic Synthesis:
2-[4-(Dimethylamino)phenyl]-1,3-dithiane is used as a reagent for the introduction of the dithiane functional group into organic molecules. Its ability to protect carbonyl groups makes it a valuable component in various organic synthesis processes.
Used in Pharmaceutical Compound Preparation:
2-[4-(Dimethylamino)phenyl]-1,3-dithiane is utilized in the preparation of different pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Anti-Inflammatory Applications:
2-[4-(Dimethylamino)phenyl]-1,3-dithiane has been studied for its potential as an anti-inflammatory agent, which could be beneficial in treating conditions characterized by inflammation.
Used in Anti-Cancer Applications:
Research has also explored the compound's potential as an anti-cancer agent, indicating its possible role in the development of new cancer treatments.
Used in Material and Technology Development:
Furthermore, 2-[4-(Dimethylamino)phenyl]-1,3-dithiane has been considered for its potential use in the development of new materials and technologies, showcasing its broad applicability across various industries.

InChI:InChI=1/C12H17NS2/c1-13(2)11-6-4-10(5-7-11)12-14-8-3-9-15-12/h4-7,12H,3,8-9H2,1-2H3

Upstream product

• 39915-66-7 1,3-dithian-2-yl tetrafluoroborate 
• 121-69-7 N,N-dimethyl-aniline 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 628300-14-1 2,4-dichloro-3-(1,3-propylenedithio-methylene)-penta-1,4-diene 
• 109-80-8 1.3-propanedithiol 
• 55727-23-6 3‐(1,3-dithiane-2-yl)pentane-2,4-dione 
• 461024-59-9 2-(1,3-dithian-2-ylidene)malonic acid 
• 540-63-6 ethane-1,2-dithiol 
• 31362-12-6 p-(1,3-dithiolan-2-yl)-N,N-dimethylaniline 

Downstream Products

• 74955-12-7 [2-(4-Dimethylamino-phenyl)-[1,3]dithian-2-yl]-phenyl-methanone oxime 
• 74955-00-3 (2-Chloro-phenyl)-[2-(4-dimethylamino-phenyl)-[1,3]dithian-2-yl]-methanone oxime 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 461051-84-3 2-(4-N,N-dimethylphenyl)-2-triethylsilyl-1,3-dithiane 
• 461051-92-3 4-N,N-dimethylphenyl triethylsilyl ketone 
• 68289-15-6 1-(2-Chloro-phenyl)-2-(4-dimethylamino-phenyl)-ethane-1,2-dione 
• 1127955-61-6 2-(2-bromobenzyl)-2-[4-(dimethylamino)phenyl]-1,3-dithiane 

Relevant academic research and scientific papers

PhIO-Mediated oxidative dethioacetalization/dethioketalization under water-free conditions

Treatment of thioacetals and thioketals with iodosobenzene in anhydrous DCM conveniently afforded the corresponding carbonyl compounds in high yields under water-free conditions. The mechanistic studies indicate that this dethioacetalization/dethioketalization process does not need water and the oxygen of the carbonyl products comes from the hypervalent iodine reagent.

Pot-economy autooxidative condensation of 2-Aryl-2-lithio-1,3-dithianes

The autoxidative condensation of 2-aryl-2-lithio-1,3-dithianes is here reported. Treatment of 2-aryl-1,3-dithianes with n-BuLi in the absence of any electrophile leads to condensation of three molecules of 1,3-dithianes and formation of highly functionalized α-thioether ketones orthothioesters in 51-89% yields upon air exposure. The method was further expanded to benzaldehyde dithioacetals, affording corresponding orthothioesters and α-thioether ketones in 48-97% yields. The experimental results combined with density functional theory studies support a mechanism triggered by the autoxidation of 2-aryl-2-lithio-1,3-dithianes to yield a highly reactive thioester that undergoes condensation with two other molecules of 2-aryl-2-lithio-1,3-dithiane.

Mesoporous sBa-15 silica catalyst functionalized with phenylsulfonic acid groups (SbA-15-ph-So3h) as efficient nanocatalyst for chemoselective thioacetalization of carbonyl compounds

In this research a Nano acidic catalyst was prepared and its efficiency on thioacetalization of carbonyl compounds was examined. For this aim we used modified SBA-15 as support, which have been modified by phenolic and sulfonic acid. SBA-15 is a member of

Silica phenyl sulfonic acid as a solid acid heterogeneous catalyst for chemoselective thioacetalization of carbonyl compounds and dethioacetalization under mild conditions

Silica phenyl sulfonic acid (SPSA) is an effective catalyst for chemoselective thioacetalization of aldehydes in the presence of ketones under neutral conditions. In addition, a simple and an efficient procedure for deprotection of 1,3-dithianes and 1,3-dithiolanes of aromatic, aliphatic, and α,β-unsaturated aldehydes and ketones in the solvent-free to the corresponding parent carbonyl compounds was successfully carried out with SPSA in excellent yields.

Silica-supported phosphorus pentoxide: A reusable catalyst for S,S-acetalization of carbonyl groups under ambient conditions

Phosphorus pentoxide supported on silica gel (P2O 5/SiO2) efficiently acts as a highly active and reusable catalyst for cyclic and non-cyclic S,S-acetalization of a variety of carbonyl compounds under mild, solvent-free an

1,3-dibromo-5,5-dimethylhydantoin (DBH) as a mild and efficient catalyst for chemoselective thioacetalization of carbonyl compounds and dethioacetalization under mild conditions

Hydantoin bromide is an effective catalyst for chemoselective thioacetalization of aldehydes in the presence of ketones under neutral conditions. In addition, a simple and efficient procedure for the deprotection of 1,3-dithianes and 1,3-dithiolanes of ar

Chemoselective (trans)thioacetalization of carbonyl compounds with a reusable lewis acid-surfactant-combined copper bis(dodecyl sulfate) catalyst in water

A Lewis acid-surfactant-combined copper bis(dodecyl sulfate) [Cu(DS) 2] catalyst served as an efficient and reusable catalyst for the thioacetalization and transthioacetalization of carbonyl compounds and O,O-acetals in water at room temperature. Some of the major advantages of this procedure are high chemoselectivity, ease of operation and purification without any organic solvent, and high yields. Georg Thieme Verlag Stuttgart.

Synthesis of benzo[b]furans by palladium-NHC catalyzed ring closure of o-bromobenzyl ketones

The palladium-catalyzed ring closure of aryl o-bromobenzyl ketones, easily accessible from aromatic aldehydes and 2- bromobenzyl bromide, provides a straightforward route to 2-aryl- benzofurans. A study of the ring closure revealed that a heterocyclic car

Catalytic carbon-sulfur bond formation by amphoteric vanadyl triflate: exploring with thia-Michael addition, thioacetalization, and transthioacetalization reactions

A series of thiols have been examined as protic nucleophiles for Michael-type additions to α,β-unsaturated carbonyls as well as double nucleophilic condensations with aldehydes, ketones, and acetals catalyzed by amphoteric, water-tolerant vanadyl triflate under mild and neutral conditions. The newly developed C-S bond formation protocols were carried out smoothly in good to high yields in a highly chemoselective manner.

Ferric hydrogensulfate as effective and recyclable catalyst for mild dithioacetalization of aldehydes and ketones

Ferric hydrogensulfate has been found to be an extremely efficient and recyclable heterogeneous catalyst for dithioacetalization reactions. Carbonyl compounds have been successfully converted into their corresponding dithiolanes and dithianes derivatives