1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

Base Information

Chemical Name:1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole
CAS No.:335645-76-6
Molecular Formula:C₃₃H₂₄FNO₂S
Molecular Weight:517.623
Hs Code.:

1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1<i>H</i>-pyrrole

Synonyms:1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

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Chemical Property of 1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

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Technology Process of 1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

There total 4 articles about 1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 371-40-4
4-fluoroaniline

: 335645-71-1
C₃₄H₂₆O₄S₂

: 335645-76-6
1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

Guidance literature:: 4-fluoroaniline; With copper(l) chloride; copper dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

C₃₄H₂₆O₄S₂; In N,N-dimethyl-formamide; at 90 ℃; for 8h;
DOI:10.3987/com-00-9112

Reference yield:

: 16192-07-7
4-tosylacetonitrile

: 335645-76-6
1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi

1.3: 51 percent / tetrahydrofuran / -78 °C

2.1: 89 percent / Cu(OAc)2 / methanol; pyridine / 20 °C

3.1: CuCl; CuCl₂ / dimethylformamide / 0.25 h / 20 °C

3.2: 63 percent / dimethylformamide / 8 h / 90 °C

With n-butyllithium; copper diacetate; copper(l) chloride; copper dichloride; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-00-9112

Reference yield:

: 100-52-7
benzaldehyde

: 335645-76-6
1-(4-fluoro-phenyl)-2-phenyl-5-[4-phenyl-3-(toluene-4-sulfonyl)-but-3-en-1-ynyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi

1.3: 51 percent / tetrahydrofuran / -78 °C

2.1: 89 percent / Cu(OAc)2 / methanol; pyridine / 20 °C

3.1: CuCl; CuCl₂ / dimethylformamide / 0.25 h / 20 °C

3.2: 63 percent / dimethylformamide / 8 h / 90 °C

With n-butyllithium; copper diacetate; copper(l) chloride; copper dichloride; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.3987/com-00-9112