{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

Base Information

Chemical Name:{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol
CAS No.:716369-21-0
Molecular Formula:C₁₉H₁₉NO₂Se
Molecular Weight:372.325
Hs Code.:

Synonyms:{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

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Chemical Property of {2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

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Technology Process of {2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

There total 10 articles about {2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 716369-15-2
(4R)-(tert-butyl-dimethyl-silanyloxymethyl)-2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazole

: 716369-21-0
{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1039/b316502g

Reference yield: 76.0%

: 716369-13-0
2-[2-(3-phenyl-allylselanyl)-phenyl]-(4R)-(triisopropyl-silanyloxymethyl)-4,5-dihydro-oxazole

: 716369-21-0
{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1039/b316502g

Reference yield:

: 7154-66-7
2-bromobenzoic acid chloride

: 716369-21-0
{2-[2-(3-phenyl-allylselanyl)-phenyl]-4,5-dihydro-oxazol-(4S)-yl}-methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 72 percent / DMAP; Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: 70 percent / Et₃N / CH₂Cl₂ / 2 h / 2 °C

3.1: 71 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

4.1: 70 percent / Et₃N; DMAP; TsCl / CH₂Cl₂ / 12 h / 20 °C

5.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

5.2: Se / tetrahydrofuran; pentane / 1 h / -78 - 0 °C

5.3: 62 percent / tetrahydrofuran; pentane / 1 h / 0 °C

6.1: 76 percent / acetic acid; TBAF / tetrahydrofuran / 1 h / 20 °C

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; tert.-butyl lithium; acetic acid; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/b316502g