3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

Base Information

Chemical Name:3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine
CAS No.:151323-54-5
Molecular Formula:C₄₄H₄₀F₃N₇O₂S
Molecular Weight:787.909
Hs Code.:

3-<(trifluoromethanesulfonamido)methyl>-2-<N-butyl-N-<<2'-<2-(triphenylmethyl)-2H-tetrazol-5-yl>biphenyl-4-yl>methyl>amino>pyridine

Synonyms:3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

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Chemical Property of 3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

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Technology Process of 3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

There total 4 articles about 3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 151323-53-4
3-(aminomethyl)-2-biphenyl-4-yl>methyl>amino>pyridine

: 151323-54-5
3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at -20 ℃; for 2h;
DOI:10.1021/jm00070a012

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 151323-54-5
3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / propan-2-ol / Heating

2: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

3: 79 percent / LiAlH₄ / diethyl ether / 1 h / Heating

4: 40 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 2 h / -20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; lithium hexamethyldisilazane; In diethyl ether; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00070a012

Reference yield:

: 74611-50-0
2-(butylamino)pyridine-3-carbonitrile

: 151323-54-5
3-<(trifluoromethanesulfonamido)methyl>-2-biphenyl-4-yl>methyl>amino>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

2: 79 percent / LiAlH₄ / diethyl ether / 1 h / Heating

3: 40 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / 2 h / -20 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; lithium hexamethyldisilazane; In diethyl ether; dichloromethane;
DOI:10.1021/jm00070a012