1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Base Information

Chemical Name:1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid
CAS No.:1396006-71-5
Molecular Formula:C₂₈H₂₆N₄O₄
Molecular Weight:482.539
Hs Code.:

Synonyms:1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Suppliers and Price of 1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ro6842262
10mg
$ 215.00

Tocris
Ro6842262 ≥98%(HPLC)
50
$ 1001.00

Tocris
Ro6842262 ≥98%(HPLC)
10
$ 238.00

Total 9 raw suppliers

Chemical Property of 1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ro6842262 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Ro 6842262 is a potent lysophosphatidic acid receptor-1 (LPA1) antagonist.

Technology Process of 1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

There total 12 articles about 1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.5%

: 1396007-94-5
1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

: 1396006-71-5
1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 5h;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1396006-71-5
1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide; copper diacetate / methanol / 23 h / 20 °C

2: toluene / 4.5 h / 150 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

6: water; lithium hydroxide / tetrahydrofuran / 5 h / 60 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; diphenyl phosphoryl azide; water; copper diacetate; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; 5: |Suzuki Coupling;

Reference yield:

: 2101-88-4
1-azido-4-bromobenzene

: 1396006-71-5
1-[4’-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biphenyl]-4-yl]cyclo-propanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 4.5 h / 150 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

5: water; lithium hydroxide / tetrahydrofuran / 5 h / 60 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; diphenyl phosphoryl azide; water; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; toluene; 4: |Suzuki Coupling;