1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester
CAS No.:1396007-94-5
Molecular Formula:C₂₉H₂₈N₄O₄
Molecular Weight:496.566
Hs Code.:

Synonyms:1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

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Chemical Property of 1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

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Technology Process of 1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

There total 9 articles about 1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

: 1396007-93-4
[3-(4-bromo-phenyl)-5-methyl-3H-[1,2,3]triazol-4-yl]-carbamic acid (R)-1-phenyl-ethyl ester

: 1396007-85-4
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarboxylic acid methyl ester

: 1396007-94-5
1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; toluene; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1396007-94-5
1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide; copper diacetate / methanol / 23 h / 20 °C

2: toluene / 4.5 h / 150 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

4: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; diphenyl phosphoryl azide; water; copper diacetate; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; 5: |Suzuki Coupling;

Reference yield:

: 2101-88-4
1-azido-4-bromobenzene

: 1396007-94-5
1-{4'-[4-methyl-5-((R)-1-phenyl-ethoxycarbonylamino)-1H-[1,2,3]triazol-1-yl]biphenyl-4-yl}cyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 4.5 h / 150 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 65 °C / Inert atmosphere

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate / toluene; water / 4 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; diphenyl phosphoryl azide; water; palladium diacetate; triethylamine; lithium hydroxide; In tetrahydrofuran; water; toluene; 4: |Suzuki Coupling;