trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Name:trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol
CAS No.:1350325-36-8
Molecular Formula:C₂₅H₂₄Cl₂F₂N₄O
Molecular Weight:505.395
Hs Code.:

Synonyms:trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Property of trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Technology Process of trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

There total 17 articles about trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350325-39-1
C₃₁H₃₈Cl₂F₂N₄OSi

: 1350325-36-8
trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: C₃₁H₃₈Cl₂F₂N₄OSi; With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; pH=~ 9;

Reference yield:

: 178813-77-9
2,6-dichloro-3-fluorobenzaldehyde

: 1350325-36-8
trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

4.1: disodium hydrogenphosphate; methanol / tetrahydrofuran / 1.5 h / -20 - -5 °C

5.1: hydrogenchloride; water / tetrahydrofuran / 0.5 h / 20 °C

5.2: pH ~ 9

With hydrogenchloride; methanol; potassium fluoride; disodium hydrogenphosphate; n-butyllithium; water; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water;

Reference yield:

: 178813-78-0
2,6?dichloro?3?fluorobenzoic acid

: 1350325-36-8
trans-4-(4-{3-[1-(2,6-Dichloro-3-fluorophenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 12 h / Reflux

2.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0.5 h / -7 - -2 °C

3.1: potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

4.2: 1 h / -78 - 20 °C

5.1: potassium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 90 °C / Inert atmosphere

6.1: disodium hydrogenphosphate; methanol / tetrahydrofuran / 1.5 h / -20 - -5 °C

7.1: hydrogenchloride; water / tetrahydrofuran / 0.5 h / 20 °C

7.2: pH ~ 9

With hydrogenchloride; methanol; potassium fluoride; sodium hypochlorite; disodium hydrogenphosphate; n-butyllithium; borane-THF; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; sodium hydrogencarbonate; sodium bromide; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water;